Covid-19 Vaccine Research, Development, Ingredients and Reactions

[AH173]

My local boe just just posted the June 4th announcement about vaccine information on its electronic information board. I really appreciate the announcement.

 

Thank you Jehovah!

 

 

[Tortuga]

1 minute ago, AH173 said:

My local boe just just posted the June 4th announcement about vaccine information on its electronic information board. I really appreciate the announcement.

 

Thank you Jehovah!

 

 

I saw the announcement too. Very interesting.

[Mykyl]

1 hour ago, AH173 said:

My local boe just just posted the June 4th announcement about vaccine information on its electronic information board. I really appreciate the announcement.

 

Thank you Jehovah!

 

 

Which one was that please? I don’t recall. 

[Tortuga]

5 minutes ago, Mykyl said:

Which one was that please? I don’t recall. 

If you haven't heard it or seen it yet, you will shortly.

 

We generally allow announcements to be discussed here after it has been made public in at least one congregation, however it would be kind to put spoilers in a spoilers tag for those that want to wait until it's announced in their congregation.

Edited June 5, 2021 by Tortuga

[Sofia]

6 hours ago, Tortuga said:

I saw the announcement too. Very interesting.

I got it today in portuguese too after the W study. Interesting. Showing loving kindness and leaving decisions up to us about vaccines.

[Sofia]

This weeks most recent research on COVID-19:

 

How dangerous is Delta?

Preliminary data from the UK suggests that infections with the B1617.2 (Delta) variant could be more likely to require hospitalization, but more data are needed to confirm this. The positive news is that its transmissibility is not as high as initially thought (40-50% higher than Alpha instead of 75% higher). Plus, full vaccination remains effective against disease caused by this variant. Only 3.7% of Delta cases occurred in fully vaccinated people. The Delta variant in England now accounts for 73% of sequenced cases.

Beware this summer

A study in collaboration with the SeqCOVID-SPAIN consortium shows that a variant (EU1) that emerged in Spain in early summer of 2020 quickly spread across Europe. This was not due to increased transmissibility but to more travel and less screening and containment.

Predictor of death

The presence of SARS-CoV-2 RNA in blood was identified as the most important predictor of mortality in patients with severe COVID-19.

Long-lasting antibodies

Repeated testing of IgM, IgG, anti-RBD IgG, and NAb titers in 215 COVID-19 patients during 10 months shows a very small decline after 10 months (except for IgM), regardless of age or severity of illness.

Latest on treatments

Up the nose

A single intranasal dose of an engineered IgM neutralising antibody conferred prophylactic and therapeutic efficacy against COVID-19 in mice, even when infected with P.1 or B1.351 variants. The engineered IgM is >200-fold more potent than its parental IgG in neutralizing SARS-CoV-2 and all major variants, in vitro.

Under the skin

The FDA authorised the subcutaneous delivery of Regeneron’s antibody cocktail (REGEN-COV) in non-hospitalized patients, which showed it reduced of hospitalisation or death by 70% in high-risk patients.

The cocktail retains neutralization potency against all current SARS-CoV-2 Variants of Concern (VOC) and of Interest (VOI), according to a study published this week.

And on vaccines

Also under the skin

An Australian team developed a high-density microarray patch that delivers SARS-CoV-2 spike proteins directly to the skin. One single dose of the patch induced good cellular and antibody responses in mice, even against circulating variants, and protected them against disease, according to a study that has not yet been peer-reviewed.

Combining vaccines

Four studies (not yet peer reviewed) posted this week show that a first dose of the AstraZeneca vaccine followed by a second dose of the Pfizer vaccine is well tolerated and induces potent humoral and cellular responses. Three of the studies (one from Spain, and two from Germany) did not include a comparison group vaccinated with two doses of AstraZeneca, but a fourth small study (also in Germany) did. This study showed that heterologous vaccination led to a significant 11.5-fold increase in anti-Spike IgG, as compared to the 2.9-fold increase after homologous AZ/AZ vaccination. It also induced significantly higher frequencies of Spike-specific CD4 and CD8 T cells and, in particular, higher titers of neutralizing antibodies against the B.1.351 (beta) and the P.1 (gamma) variants of concern.

Safety

Some cases of myocarditis and pericarditis in young adults have been reported after vaccination with mRNA vaccines, more frequently after the second dose. In most cases, the symptoms improve rapidly after medications and rest.

More than 2 billion doses of vaccines have been administered worldwide. Poorer countries have received less than 1%.

 

 

 

 

Edited June 9, 2021 by Sofia

[Sofia]

Id like to highlight this research to make you all feel more comfortable, though keep obeying authorities and the GB directions PLEASE.

 

Long-lasting antibodies

Repeated testing of IgM, IgG, anti-RBD IgG, and NAb titers in 215 COVID-19 patients during 10 months shows a very small decline after 10 months (except for IgM), regardless of age or severity of illness.

[hatcheckgirl]

11 hours ago, Sofia said:

Also under the skin

An Australian team developed a high-density microarray patch that delivers SARS-CoV-2 spike proteins directly to the skin. One single dose of the patch induced good cellular and antibody responses in mice, even against circulating variants, and protected them against disease, according to a study that has not yet been peer-reviewed

I like this option very much! No needles!! 😆

[Sofia]

People already infected with COVID-19 gain no additional benefits from vaccination

Source: https://www.msn.com/en-us/health/medical/people-already-infected-with-covid-19-gain-no-additional-benefits-from-vaccination-study/ar-AAKQba2?li=BBnbfcL&pfr=1

 

study scientific print: https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v2

 

The news was welcomed by Sen. Rand Paul, who celebrated the results on Twitter Tuesday.

“Great news! Cleveland clinic study of 52,238 employees shows unvaccinated people who have had COVID 19 have no difference in re-infection rate than people who had COVID 19 and who took the vaccine,” Paul said.

This comes after Paul generated controversy in recent weeks after publicly stating he was refusing the vaccine due to his previous COVID-19 infection.

"Until they show me evidence that people who have already had the infection are dying in large numbers or being hospitalized or getting very sick, I just made my own personal decision that I'm not getting vaccinated because I've already had the disease and I have natural immunity,” Paul said last month.

Edited June 10, 2021 by Sofia

[Amygdala]

So holding our breath and going in for J&J tomorrow morning. Any unexpected info about the J&J vaccine I should know about, please post!

[BLEmom]

1 hour ago, Lieblingskind said:

So holding our breath and going in for J&J tomorrow morning. Any unexpected info about the J&J vaccine I should know about, please post!

My two sons had this one on Saturday. One had no reaction and one got chills the first night. Since then nothing. 

[Ms. Piffle]

My son got bad chills the first night.  Also tingling in the arm he got the shot in.  Also headache, nausea.  Next day all was fine except a little nausea and headache.  The follow day he felt fine.  My son in law got slight headache and nausea only the day after the shot.  Lasted just a day.

 

Several Brothers and sisters in the congregation got the J&J and had no reactions at all.  

Edited June 10, 2021 by Polka Dot

[Qapla]

My wife had the J&J - other than a slightly sore arm from being jabbed - no reaction.

 

 

[Amygdala]

From what I've read so long as I don't get a nasty headache, double-vision, or lose feeling on one side, all the other side effects (if any) are not dangerous. Maybe I should take an aspirin beforehand??

[rocket]

1 hour ago, Lieblingskind said:

From what I've read so long as I don't get a nasty headache, double-vision, or lose feeling on one side, all the other side effects (if any) are not dangerous. Maybe I should take an aspirin beforehand??

I have read that taking an aspirin ahead of the jab is not good as it will make the jab less effective. But who really knows.

[califlorican]

9 hours ago, Lieblingskind said:

From what I've read so long as I don't get a nasty headache, double-vision, or lose feeling on one side, all the other side effects (if any) are not dangerous. Maybe I should take an aspirin beforehand??

We were advised to not take pain meds beforehand. Not sure if it really makes a big difference, but just to be sure we didn’t, We did take some afterwards, but our reactions were not very serious thankfully!

[Amygdala]

So I didn't take aspirin before, but after. I am fine, but my husband is feeling bad today.  I take Olive leaf capsules regularly which naturally kills viruses, plus zinc and vit.D so perhaps my immune system is ok with the vaccine working at the moment.

On 6/11/2021 at 6:14 AM, califlorican said:

We were advised to not take pain meds beforehand.

I meant more because of the blood clotting issue and taking aspirin. I took baby aspirin while I was pregnant to avoid clotting as well.

[WilliamChew]

157 suspected serious reactions to Covid-19 jabs reported out of nearly 3.7 million doses given in Singapore

 

There have been 157 reports here of suspected reactions to the Covid-19 vaccine severe enough to be life-threatening or result in hospitalisation, among other serious conditions.

 

However, no deaths have been linked to the jab, the Health Sciences Authority (HSA) said on Friday (June 11).

 

These "suspected serious adverse events" made up 0.004 per cent of the almost 3.7 million doses of Pfizer-BioNTech and Moderna jabs administered till May 23

 

These serious cases form part of the 4,704 "suspected adverse events reports" that HSA received till May 23.

[Old]

1 minute ago, WilliamChew said:

157 suspected serious reactions to Covid-19 jabs reported out of nearly 3.7 million doses given in Singapore

 

There have been 157 reports here of suspected reactions to the Covid-19 vaccine severe enough to be life-threatening or result in hospitalisation, among other serious conditions.

 

However, no deaths have been linked to the jab, the Health Sciences Authority (HSA) said on Friday (June 11).

 

These "suspected serious adverse events" made up 0.004 per cent of the almost 3.7 million doses of Pfizer-BioNTech and Moderna jabs administered till May 23

 

These serious cases form part of the 4,704 "suspected adverse events reports" that HSA received till May 23.

Can you do the math for me? I boggle easily. 

[WilliamChew]

9 hours ago, Old said:

Can you do the math for me? I boggle easily. 

Which metric are you referring to?

 

 

[califlorican]

15 hours ago, WilliamChew said:

Which metric are you referring to?

 

 

I think it’s 157 reaction reports compared to 3.7 million vaccinated. It’s .004% 😅

[Sofia]

[Evidence published between 09/06/2021 and 15/06/2021]

Looking for bat viruses

Researchers in the Chinese province of Yunnan province discovered 24 new coronaviruses in bats, including what could be a very close relative to SARS-CoV-2

More on Delta

Data from England and from Scotland indicate that Delta (B1617.2) is 40-60% more transmissible than Alpha (B1117) and the risk of hospitalization with is 2x higher in those with the Delta variant as compared to Alpha. Two doses of the Oxford–AstraZeneca and Pfizer–BioNTech COVID-19 vaccines were highly effective (96% and 92%, respectively) in reducing the risk of SARS-CoV-2 hospitalisation in people infected with the Delta variant. No rise in reinfections is observed for the moment.

According to sources from England, the Delta variant may be associated with different symptoms than the original variant. The most frequent symptom now is headache, followed by sore throat, runny nose, and fever (more like a “bad cold” in young people).

Ageing cells

Senescent cells become hyperinflammatory in response to pathogens, and aged mice were more disposed to severe inflammation and death from infection with a coronavirus related to SARS-CoV-2. These findings would help to explain why elderly and chronically ill patients are especially vulnerable to COVID19.

Long-lived immunity

Two more studies point to a robust and long-lasting immunity after infection. One study found long-lasting plasma cells (which produce anti-Spike antibodies) in the bone marrow of patients 7-8 months after infection, even in those who experienced mild symptoms. Another study found that virus-specific B cells remain relatively stable 6 to 12 months after infection, and that one single vaccine dose can induce high levels of neutralising antibodies effective against all circulating variants.

Anticoagulants and COVID-19

Aspirin doesn't improve chances of survival for patients hospitalized with COVID-19, according to the RECOVERY trial. However, anticoagulants given as prophylaxis may increase survival of patients hospitalized with COVID-19.

More on vaccines

Another highly effective vaccine

Novavax announced Phase 3 results for its protein subunit vaccine: 93% efficacy against moderate or severe disease caused by circulating variants of concern, and 91% efficacy in high-risk populations (over 65 or with comorbidities). The study enrolled 29,960 participants in the U.S. and Mexico. A total of 77 cases were observed: 63 in the placebo group (of which 10 moderate and four severe) and 14 in the vaccine group.

Lower risk of infection

COVID-19 vaccination reduced the number of new SARS-CoV-2 infections, with the largest benefit received after two vaccinations and against symptomatic and high viral burden infections, and with no evidence of a difference between the Pfizer and AstraZeneca vaccines, according to a study in the UK.

Another study in Israel with over 6,000 individuals estimated Pfizer’s vaccine reduced the risk of infection by 61% two weeks after the first dose and 89% two weeks after two vaccine doses.

T cells and variants

A study of antibody and T cell responses from individuals vaccinated with Johnson & Johnson’s vaccine shows reduced neutralizing antibody activity against P.1 (Gamma) and B1.351 (Beta) variants, but T cell responses against all variants were similar.

[On the huh]

36 minutes ago, Sofia said:

The most frequent symptom now is headache, followed by sore throat, runny nose, and fever (more like a “bad cold” in young people).

This was on the news today.  With those symptoms you may think you have a summer cold, so get yourself tested to be sure.

[Sofia]

18 minutes ago, On the huh said:

This was on the news today.  With those symptoms you may think you have a summer cold, so get yourself tested to be sure.

Yep…🤔🤔

[Naturale]

Expert haematologists advise against taking aspirin after AstraZeneca Covid-19 vaccine because it will not affect the occurrence of vaccine-associated thrombosis and thrombocytopenia (VATT), which is driven by an immune response to something in the AstraZeneca Covid-19 vaccine.

Furthermore, one of the problems with VATT is a low platelet count which means there is increased risk of bleeding. Aspirin will make this worse