Covid-19 Vaccine Research, Development, Ingredients and Reactions

[Amygdala]

Very interesting, Naturale. I guess time will tell regarding my J&J vaccination. Day 4 now post-vax.

 

https://www.msn.com/en-us/health/medical/what-are-the-blood-clots-associated-with-the-johnson-26-johnson-covid-19-vaccine-4-questions-answered/ar-AAKEXvx

Quote

As of April 24, 2021, out of the 8 million people vaccinated with the Johnson & Johnson vaccine in the U.S., about 16 people have developed these blood clots. The clots occurred from six to 13 days after immunization, and the majority were in women between the ages of 18 and 48.

 

[Qapla]

I guess that means that 7,999,984 didn't develop any clots ...

 

 

[Amygdala]

Yes the risk is low. Why we chose the 1x jab.

[Amygdala]

Just hopefully it wasn’t the bad batch…🤭

[rocket]

Interesting how so many panic over 16 developing blood clots out of 7+ million doses given. Now compare that to one study on aspirin.

 

https://pubmed.ncbi.nlm.nih.gov/16086703/

 

Quote

Death rate attributed to NSAID/aspirin use was between 21.0 and 24.8 cases/million people, respectively, or 15.3 deaths/100,000 NSAID/aspirin users. 

If that study reflected a true world wide case study, how much greater risk to taking an aspirin that getting the jab?

[Old]

7 minutes ago, rocket said:

Interesting how so many panic over 16 developing blood clots out of 7+ million doses given. Now compare that to one study on aspirin.

 

https://pubmed.ncbi.nlm.nih.gov/16086703/

 

If that study reflected a true world wide case study, how much greater risk to taking an aspirin that getting the jab?

Dangerous ground here Lynn, be very careful, inserting common sense into this topic might have an adverse reaction.

  

[Sofia]

1 hour ago, rocket said:

Interesting how so many panic over 16 developing blood clots out of 7+ million doses given. Now compare that to one study on aspirin.

 

https://pubmed.ncbi.nlm.nih.gov/16086703/

 

If that study reflected a true world wide case study, how much greater risk to taking an aspirin that getting the jab?

Im severely allergic to aspirin… 😳

[Qapla]

58 minutes ago, Sofia said:

I'm severely allergic to aspirin…

 

And I am severely allergic to Novocain, NutraSweet and Enalapril - but I don't advocate others should avoid them just because they bother me.

 

 

One thing I am not allergic to is hard work ...

 

 

 

 

... I can lay down next to it and go right to sleep  

[WilliamChew]

Some statistics showing how vaccination reduces severity of covid-19. Of the 158 vaccinated, none of those without pre-existing conditions required supplemental oxygen.
 

https://www.channelnewsasia.com/news/singapore/covid-19-vaccination-slots-pfizer-moderna-shorter-wait-faster-15039748

 

On Friday, Mr Ong (Singapore's health minister) provided data showing how more cases of unvaccinated COVID-19 patients required supplemental oxygen.

 

A total of 629 COVID-19 local cases reported since Apr 11 were not fully vaccinated, said Mr Ong. Of those, about 8.6 per cent, or 54 patients, subsequently required supplemental oxygen or were warded in the intensive care unit, he said.

 

In contrast, only two out of 158 vaccinated COVID-19 patients - about 1.3 per cent - required supplemental oxygen. The two patients had pre-existing conditions, according to Mr Ong.

[➕👇 ꓤꓱꓷꓠꓵ🎵Tone]

157 suspected serious reactions to Covid-19 jabs reported out of nearly 3.7 million doses given in Singapore
 
There have been 157 reports here of suspected reactions...
However, no deaths have been linked to the jab...
These "suspected serious adverse events" made up 0.004 per cent of the almost 3.7 million doses of Pfizer-BioNTech and Moderna jabs administered till May 23...

Australia reports 2 deaths from the 3.6Million AstraZeneca vaccine jabs given.
The Health Directive is now to issue Pfizer to under 59's.
The rest of us (expendable) oldies qualify to get the AstraZeneca for free...



Peter Dutton says death linked to AstraZeneca COVID vaccine is a tragedy, but Australians need to put risks 'into perspective' - ABC News https://www.abc.net.au/news/2021-06-11/blood-lots-experts-urge-calm-covid-astrazeneca-vaccine/100206846 

Old (Downunder) Tone

[Sofia]

[Evidence published between 16/06/2021 and 22/06/2021]

Birthday…

A study using health care data of 2.9 million households in the US during the first 10 months of 2020 shows that small and informal social gatherings, such as birthdays, and in particular, children’s birthdays, were potentially an important source of SARS-CoV-2 transmission.

Immunity to Delta

Antibodies from convalescent patients or vaccinated individuals have reduced neutralising activity against the Delta variant's sublineages (B.1.617.1 and B.1.617.2) but there is no evidence of widespread antibody escape, as seen with the Beta variant (B.1.351). The study results however suggest that individuals previously infected with Beta or Gamma (P.1) may be more susceptible to reinfection by Delta.

The latest report on the Delta variant in the UK has some good news: while Delta has clearly led to an increase in hospitalizations, their length is decreasing, likely due to younger patients. Two doses of vaccine (AstraZeneca or Pfizer) remain highly effective against hospitalisations, and no increase in reinfections with Delta has been observed to date.

Low rates of reinfection

Reinfection was identified in 0.7% of 9,119 patients that were followed up after SARS-CoV-2 infection. The mean period between two positive tests was 116 days. Asthma and nicotine dependence/tobacco use were associated with re-infection.

Enter Lambda

The WHO has classified the Lambda COVID-19 variant (C.37) as global 'variant of interest' due to its elevated presence in Peru and rest of South America. Lambda carries mutations that might increase its transmissibility or help it evade immunity, but the evidence remains very limited.

More on treatments

Antibody cocktails

Preliminary results from the RECOVERY trial in UK shows a clinical benefit for Regeneron’s cocktail of monoclonal antibodies in hospitalised patients who did not produce virus-specific antibodies: the drug reduced mortality by 20% in seronegative patients, as compared with usual care alone.

Decoys

Inhaled nanovesicles containing the ACE2 receptor prevented COVID-19 in macaques challenged with SARS-CoV-2. These ACE2 ‘nanodecoys’ derived from human lung cells can bind and neutralize SARS-CoV-2 and protect the host lung cells from infection.

Not all mRNA vaccines are equal

An interim analysis of CureVac’s mRNA vaccine showed a disappointing 47% efficacy against symptomatic infections. The Phase 3 trial enrolled approximately 40,000 participants in ten countries in Latin America and Europe. Although the reasons are not yet known, the lower efficacy could be related to the fact that, in contrast to Pfizer-BioNTech and Moderna, the company did not modify the chemical composition of the mRNA.

COVID-flu combo

Novavax publishes a first study that demonstrates the safety, immunogenicity, and efficacy profile of its COVID-19 vaccine when co-administered with seasonal influenza vaccines.

Vaccine ‘apartheid’

2.7 billion doses have been administered globally. Less than 1% of people in low-income countries have received at least one dose. In an interview with Science, WHO Director General Dr. Tedros talks about his exasperation at this vaccine inequity, which is leading to a two-track pandemic. South America is COVID-19’s global hot spot, with 8 times the world’s death rate, but cases are rising at an alarming pace in many African countries.

[BLEmom]

Hubby and I got 2nd dose of Phizer today.  As we are in the tiny room with the pharmacist, she proceeds to tell us she was hospitalized for a week after her first shot. Myocarditis. She’s afraid to get the 2nd one. Then she lets us know to take a photo of our card because people are stealing them. 
 

Ummm, thanks?!?!? 😳

[pnutts]

I got my 2nd dose of Pfizer at 3 PM EDT today. Wife next Wed.

[Áine]

35 minutes ago, BLEmom said:

Hubby and I got 2nd dose of Phizer today.  As we are in the tiny room with the pharmacist, she proceeds to tell us she was hospitalized for a week after her first shot. Myocarditis. She’s afraid to get the 2nd one. Then she lets us know to take a photo of our card because people are stealing them. 
 

Ummm, thanks?!?!? 😳

Good idea to take a photo of them ! 

 

I had the same vaccine and expected side effects but didn't really get any... not even a sore arm!

 

Isn't it strange that the people are prepared to steal the cards 

 

[New World Explorer]

Pfizer, Moderna COVID-19 vaccines will get label warning over rare heart risk, FDA says

 

Wednesday’s news that U.S. experts concluded there is a “likely association” between rare cases of heart inflammation and mRNA vaccines has finally presented the Pfizer-BioNTech and Moderna shots with a dose of adversity. The FDA said it will move quickly to require the companies to add a label warning that young adults and adolescents are susceptible to the side effect.

While the Centers for Disease Control and Prevention (CDC) concluded that the benefits of the vaccine clearly outweigh risks, the verdict could compel those with apprehension to favor adenovirus-type vaccines offered by Johnson & Johnson and AstraZeneca.

 

Those shots faced safety concerns of their own earlier this year over rare but severe cases of blood clots, which led to fatalities. After an investigation, J&J's vaccine now carries a warning in the U.S. https://www.fiercepharma.com/pharma/fda-says-label-warning-coming-for-heart-inflammation-pfizer-bnt-moderna-covid-19-vaccines

[WilliamChew]

Results for the past 2 months in Singapore which has been battling with the Delta variant.

 

Seems to show that getting vaccinated against COVID-19 can lessen the severity of symptoms.

 

Unvaccinated

610 cases 9.2% developed serious illness, needing oxygen supplementation or admission into intensive care units (ICUs). Six died from complications related to COVID-19.

 

Vaccinated

289 cases. No COVID-19 fatalities

7.3% of patients who had received one dose of the vaccine requiring supplemental oxygen or admission into ICU
1% of fully vaccinated needed supplemental oxygen. None needed mechanical ventilation.

 

Older vaccinated have better protection

Those who were aged 60 and above made up 35.5 per cent of the total number of cases.

Delta variant has an age-associated severe outcome. The older a person is, the higher the risk of severe illness.

 

“In the face of the Delta variant, we continue to observe fewer symptomatic cases and fewer severe cases among those vaccinated even in the older age group,”

https://www.channelnewsasia.com/news/singapore/covid-19-vaccinations-lessen-severity-symptoms-disease-experts-15116392

 

 

[Sofia]

Should people who have recovered from COVID take a vaccine? 

Epidemiology, immunology and the clinical data all say a clear “No!”. There is no good reason to vaccinate the recovered.

 

this not anti vaccines !

It’s just to relax your minds

source: https://www.biznews.com/health/2021/06/28/covid-19-vaccine-immunity?utm_source=dlvr.it&utm_medium=twitter&amp&__twitter_impression=true

 

[AH173]

I'm glad my daughter (new rn) and mother in law did. 

[califlorican]

On 6/30/2021 at 7:08 AM, Sofia said:

Should people who have recovered from COVID take a vaccine? 

Epidemiology, immunology and the clinical data all say a clear “No!”. There is no good reason to vaccinate the recovered.

 

this not anti vaccines !

It’s just to relax your minds

source: https://www.biznews.com/health/2021/06/28/covid-19-vaccine-immunity?utm_source=dlvr.it&utm_medium=twitter&amp&__twitter_impression=true

 

I’m curious if opinions will change with more recent testing/updates, like the one here: https://www.medrxiv.org/content/10.1101/2021.06.21.21259268v1.full-text
 

Quote

Combining the model-inference estimates during the first and second pandemic waves in India, we estimated that Delta was able to escape immunity from prior wildtype infection 45.8% (95% CI: 0 – 67.6%) of the time and was 60.1% (95% CI: 46.0 – 80.8%) more infectious than wildtype SARS-CoV-2.

 

 

Edited July 1, 2021 by califlorican

[Tbs77]

Will a booster be required maybe not:

Pfizer and Moderna vaccines may provide years of protection from COVID-19
By Yasemin Saplakoglu

First Published 2 days ago

A small study suggests that mRNA vaccines may offer long-term protection as long as the virus doesn't evolve significantly.

https://www.livescience.com/mrna-covid-19-vaccines-long-term-protection.html

[dove]

As far as I have seen, there is no choice about which of the vaccines we can get. It's whatever is offered at the facility closest to you. So if one is better than the other for your age or health situation you may have to find out where and when that is and go there?

[Qapla]

Several of the places offering vaccines in our area have more than one brand and you can choose from what is available. Also, since there are so many places offering the vaccines, there does not seem to be a problem finding whatever one you would like - and none of the places are that far from each other so as to make it inconvenient to find the one you want.

 

 

Edited July 2, 2021 by Qapla

[Shawnster]

1 hour ago, Dove said:

As far as I have seen, there is no choice about which of the vaccines we can get. It's whatever is offered at the facility closest to you. So if one is better than the other for your age or health situation you may have to find out where and when that is and go there?

There are websites that you can access and find out which pharmacy in the US is providing which brand of the vaccine. Most pharmacy websires are listing which one is offered. 

 

 

[Qapla]

This is one of those sites

 

https://www.vaccines.gov/search/?medications=784db609-dc1f-45a5-bad6-8db02e79d44f&zipcode=10987&radius=25

 

(You will need to enter your own zip code - not the one for Warwick)

Edited July 2, 2021 by Qapla

[Sofia]

3 hours ago, Tbs77 said:

Will a booster be required maybe not:

Pfizer and Moderna vaccines may provide years of protection from COVID-19
By Yasemin Saplakoglu

First Published 2 days ago

A small study suggests that mRNA vaccines may offer long-term protection as long as the virus doesn't evolve significantly.

https://www.livescience.com/mrna-covid-19-vaccines-long-term-protection.html

Correct

it goes with most research been done so far