Covid-19 Vaccine Research, Development, Ingredients and Reactions

[friendlyone]

On 2/2/2021 at 2:43 PM, friendlyone said:

The first one for me is booked in for next week. The second one at the end of April.

I was booked in to have my first jab next week. It would have meant travelling about 15 miles to the vaccination centre, which would have been ok.

 

The same day I received my invitation letter to go online and book that appointment I later received a text from my doctors surgery asking me to book a jab. I phoned them up, and asked if I could go to a centre which was just a short walk away. So, cut a long story short, I had my first jab which was the AstraZeneca one yesterday late afternoon, and it went fine.

 

And yes, I've cancelled the original booking. 😇

[Naturale]

The fact is that the very first vaccines for COVID-19  are an entirely new type: mRNA vaccines. Never before have mRNA vaccines — such as the two-dose Pfizer/BioNTech and Moderna vaccines that have now received emergency use authorization from the FDA — been approved for use in any disease.   Therefore no-one can know yet what reactions people will have in the long term as a substantial amount of time would likely have to pass to see what happens.  

 

Drew Weissman, MD, PhD, of the University of Pennsylvania in Philadelphia and an early pioneer of mRNA technology,  and colleagues wrote, trials did show "moderate and in rare cases severe injection site or systemic reactions."

Their chief safety concerns, which they said should be closely watched in future trials, were about local and systemic inflammation, as well as keeping tabs on the "expressed immunogen" and on any auto-reactive antibodies.

"A possible concern could be that some mRNA-based vaccine platforms induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity," they wrote. "Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken."

The authors also noted that extracellular RNA could contribute to edema, and cited a study that showed it "promoted blood coagulation and pathological thrombus formation."

https://www.medpagetoday.com/infectiousdisease/covid19/89998+&cd=16&hl=en&ct=clnk&gl=im

Edited February 4, 2021 by Naturale

[bohemian]

link says “page not found”

[SUNRAY]

1 hour ago, bohemian said:

link says “page not found”

 

Try this link: https://www.medpagetoday.com/infectiousdisease/covid19/89998 A paper written in 2018 expressed.....Their cheif safety concerns, which they said should be closely watched in future trials, were about local and systemic inflammation, as well as keeping tabs on the "expressed immunogen" and on any auto-reactive antibodies. "A possible concern could be that some mRNA-based vaccine platforms induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity," they wrote. "Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken." The authors also noted that extracellular RNA could contribute to edema, and cited a study that showed it "promoted blood coagulation and pathological thrombus formation." "Safety will therefore need continued evaluation as different mRNA modalities and delivery systems are utilized for the first time in humans and are tested in larger patient populations..."

 

It is good to know ones are monitoring those taking mRNA vaccines for safety concerns. 

Edited February 4, 2021 by SUNRAY
spelling

[Naturale]

1 hour ago, SUNRAY said:

It is good to know ones are monitoring those taking mRNA vaccines for safety concerns. 

I found this doc re: Moderna.  I haven't read it all

https://webcache.googleusercontent.com/search?q=cache:qXRF3pOqt4sJ:https://www.fda.gov/media/144434/download+&cd=7&hl=en&ct=clnk&gl=im

Vaccines and Related Biological Products Advisory Committee Meeting

December 17, 2020

FDA Briefing Document

Moderna COVID-19 Vaccine

 

Page 50 & 51

Adverse reactions that are very uncommon or that require longer follow-up to be

detected

Following authorization of the vaccine, use in large numbers of individuals may reveal

additional, potentially less frequent and/or more serious adverse events not detected in the trial

safety population of approximately 30,000 participants over the period of follow-up at this time.

Active and passive safety surveillance will continue during the post-authorization period to

detect new safety signals.

Although the safety database revealed an imbalance of cases of Bell’s palsy (3 in the vaccine

group and 1 in the placebo group), causal relationship is less certain because the number of

cases was small and not more frequent than expected in the general population. Further signal

detection efforts for these adverse events will be informative with more widespread use of the

vaccine.

Vaccine-enhanced disease

Available data do not indicate a risk of vaccine-enhanced disease, and conversely suggest

effectiveness against severe disease within the available follow-up period. However, risk of

vaccine-enhanced disease over time, potentially associated with waning immunity, remains

unknown and needs to be evaluated further in ongoing clinical trials and in observational studies

that could be conducted following authorization and/or licensure"

Edited February 4, 2021 by Naturale

[Amygdala]

Although, yes, mRNA vaccines are a new method of creating vaccines, the newness doesn't necessarily sway me off, because the efficacy rate speaks volumes, as does the number of test participants - and never so many with any other vaccines in the past. The FDA requirement of 2 months result from vaccinated test participants would have already indicated adverse reactions. Yes ongoing, but the numbers show that this transient vaccine will do it's job from the injection of a single protein of the virus (not the 25-28 proteins the COVID virus contains), creating a proper natural immune response in the form of antibodies or t-killer cells, and from the opinions of different scientists creating a longer immunity than if someone were to catch the virus naturally.

 

 

[Witness1970]

I know a couple (Witnesses) that had a vaccine today (February 4), and my wife and I are scheduled to have the vaccine tomorrow.  

 

The couple who had the vaccine yesterday are real worriers and asked for prayers from me and my wife.  My wife is also a worrier and very hesitant to have the vaccine.  I am not a worrier.  I always just take a wait and see attitude on anything I have no control over.

 

 

[Lee49]

https://www.cnn.com/2021/02/02/health/covid-vaccine-hesitancy-questions-answered-wellness-trnd/index.html

 

If your loved one is hesitant to get the Covid-19 vaccine, share this

 

If they say: These things - ( at the web site )

[hatcheckgirl]

What exactly do the current vaccine do? Do they stop transmission or stop the severity of the disease?

 

“Do COVID-19 vaccines prevent transmission?

The goal of vaccination is, first and foremost, to stop people getting sick, says Nigel McMillan, director of infectious diseases and immunology at Menzies Health.

Sometimes, vaccines are also able to stop us from getting infected in the first place — and therefore prevent us from passing the virus onto others. This is known as sterilising immunity.

 

University of Oxford researchers this week published results of a study that found the Oxford-AstraZeneca vaccine, which most Australians are expected to get, "may have a substantial impact on transmission" of SARS-CoV-2 (the virus that causes COVID-19).
 

When it comes to COVID-19, researchers have been primarily focused on the vaccines' protective efficacy — how well they protect people from falling ill.

In clinical trials, the Pfizer vaccine was found to be 95 per cent effective at reducing disease. But whether it stopped people from getting infected in the first place isn't yet known — because it wasn't measured.”
 

With vaccine rollouts the fastest in Israel, we should know soon if the vaccine helps stop transmission.

 

“If vaccines don't completely stop the disease, then what?

The worst-case scenario isn't really bad at all.

We probably won't immediately throw open our borders (or throw away our masks), but simply reducing the severity of COVID-19 should slow the spread of the disease, should outbreaks occur... Having fewer sick people spreading the disease will ease the burden on healthcare systems and contact tracing teams.”

 

https://www.abc.net.au/news/health/2021-02-05/covid-19-vaccines-do-they-prevent-coronavirus-transmission/13121348

 

 

 

 

 

[Dustparticle]

I don’t know this been mention or not, but at least 8,600 friends had died from this virus.

[Margaret]

Service meeting this morning quoted 10K of our brothers have died

[Omoyeme]

28 minutes ago, Margaret said:

Service meeting this morning quoted 10K of our brothers have died

8,600 is the number we received at our mid-week meeting this week. The source was a letter from the U.S. branch.

 

[Qapla]

Yes, the number from the Branch was stated as :  "Worldwide over 8,600 of our brothers and sisters have died from the virus."

[Margaret]

It was an Elder who said he just checked this morning, thursday

[Amygdala]

I should clarify my comments about the injection of the single protein - it is a messaging blueprint of the spike protein which stems from the surface of the virus, and not an injection of the virus protein itself. So it’s signaling to the body to create this spike protein to build the needed immune response, and no form of the virus itself goes into the system. It targets the cytoplasm of the cell, so does not go into the nucleas, therefore no DNA is being affected. After the mRNA has done it’s job, it is excreted out of the body. The cool temperatures needed to store the vaccine is in order for the fatty lipids to carry the mRNA and not dissolve from heat.

 

 

Edited February 5, 2021 by Lieblingskind

[Naturale]

 Novel mRNA vaccines have no precedence of regulatory approval.  Moreover, the MHRA does not have an established bank of historical data on their possible long term adverse and unintended effects.  

 

 

Edited February 5, 2021 by Naturale

[Tortuga]

11 hours ago, Naturale said:

 

Sister, can you please explain what your point is? I am trying to catch up on this topic and I can't see the value in most of your comments. You are apparently staunchly against vaccinations and repeatedly belabor your point, however I can't see how that contributes to the conversation or this site. Since this seems to be one of the few topics that you participate in I'm trying to understand how your comments benefit the world wide association of your brothers and sisters.

Edited February 5, 2021 by Tortuga

[rocket]

https://www.msn.com/en-us/health/medical/we-need-to-be-prepared-fda-will-draft-guidance-to-work-with-vaccine-drug-and-testing-companies-on-covid-19-variants/ar-BB1dphzO?li=BBnb7Kz

 

FDA will draft guidance to work with vaccine, drug and testing companies on COVID-19 variants

 

"We must prepare for all eventualities," 

[Fallbrookian]

4 hours ago, Naturale said:

 Novel mRNA vaccines have no precedence of regulatory approval.  Moreover, the MHRA does not have an established bank of historical data on their possible long term adverse and unintended effects.  

 

 

Thank you Susanna, I value your comments and the information shared by you and others helps to see both sides of the Covid vaccine discussion. It’s good to have more then one opinion, especially on such an important decision as our health.

[SUNRAY]

1 hour ago, Tortuga said:

Sister, can you please explain what your point is? I am trying to catch up on this topic and I can't see the value in most of your comments. You are apparently staunchly against vaccinations and repeatedly belabor your point, however I can't see how that contributes to the conversation or this site. Since this seems to be one of the few topics that you participate in I'm trying to understand how your comments benefit the world wide association of your brothers and sisters.

Hi Richard..It is difficult for some to appreciate some posts, but for those of us who are chemical sensitive and are immune deficient because of a retro virus..like myself and my husband and others here, we are concerned about the ingredients in any vaccine being injected into us. Even the companies who have developed these vaccines, and even government agencies warn those with previous allergic reactions to vaccines or to any ingredient in a vaccine to use caution, or in some cases not to take some vaccines..PEG, for instance has been mentioned as the possible cause of a serious side effects..stop breathing..passing out..requiring an epi-pen and sometimes hospitalization! The concern for long term effects from some vaccinations, is a real one for me. I appreciate ones posting their research, even if they don't personally yet suffer from long term effects. I view it as loving, and that is why I started this topic..as well as those who get vaccinated sharing any side effects which I appreciate. Meanwhile, some post their opinion that if ones don't get vaccinated it is unloving..

..Of interest, it is that Ivermectin, a parasite perscription, is  now being used as an approved "drug"  (really from a natural source..discovered in soil in Japan) in many countries, and is allowed now by NIH to be persceibed by doctors in the US..In Broward County and the Florida Keys it has been approved for use by 3 hospitals, and one doctor has been perscribing it both as a prophelactic and in hospital treatmment along with steroids, vit. C and Zinc  and an antibiotic. The evidence is overwhelming that this treatment can stop the virus early, and if already in hospital, turn around the virus effect before one is put on a ventilator..My point is..just because one chooses not to vaccinate does not mean they are not taking precautions to protect their own health and that of others. And if ones choose to take a vaccine, and they are not concerned about ingredients or long term effects, that is their business and a personal decision. I hope this can help you understand, and when @ Naturale posts..a simple reply that you appreciate her research would be kind. 

[Mykyl]

17 minutes ago, Nancy M said:

 

 

Edited February 5, 2021 by Mykyl
No point

[Tortuga]

23 minutes ago, SUNRAY said:

Hi Richard..It is difficult for some to appreciate some posts, but for those of us who are chemical sensitive and are immune deficient because of a retro virus..like myself and my husband and others here, we are concerned about the ingredients in any vaccine being injected into us

I understand. Have you received the information that you are looking for?

 

We all appreciate useful information but some of the comments here seem to be more of a campaign both pro and con, so I'm trying to understand where we draw the line between campaigning and sharing useful information. I appreciate your perspective.

Edited February 5, 2021 by Tortuga

[Jmystro]

Update:

Wife:  Day after 2nd vaccine, missed 1 day of work due to fever, body aches, chills and a headache.  Back to work and feeling a lot better today.

 

Myself:  Practically no side effects, was a

little sluggish the morning after but went away by noon.

[SUNRAY]

11 minutes ago, Tortuga said:

I understand. Have you received the information that you are looking for?

 

We all appreciate useful information but some of the comments here seem to be more of a campaign both pro and con, so I'm trying to understand where we draw the line between campaigning and sharing useful information. I appreciate your perspective.

Richard..let me apologize to you if I seemed disrespectful..

As to if there is enough information about ingredients yet? Well, I believe we have been discussing 2 vaccines. Already there are 2 more approved and and at least one more in the pipeline. They each have their own ingredients, and own side effects..so I would say no to your question. I research a lot about newer vaccines, but for the most part, some companies are holding back on sharing information..If ones here have a history working, let's say, in a drug manufacuring company or other related company, maybe they would have access to information I don't. A simple statement: "I found  this information interesting, and would like to share" and a link, might be a way for ones posting to not come across in an offensive way.

 

[SUNRAY]

23 minutes ago, Jmystro said:

Update:

Wife:  Day after 2nd vaccine, missed 1 day of work due to fever, body aches, chills and a headache.  Back to work and feeling a lot better today.

 

Myself:  Practically no side effects, was a

little sluggish the morning after but went away by noon.

Thank you for keeping us updated! Please continue to do so..some symptoms may show up later. Long term side effects are yet unknown..so please keep us informed. I am glad you are back to work, and I hope you will be more protected from covid infection.